Localization and Function of Dopamine Receptors in the Subthalamic 1 Nucleus of Normal and Parkinsonian Monkeys
نویسندگان
چکیده
Author contributions: AG designed and supervised experiments, analyzed data and wrote the 14 manuscript, XH performed the experiments and analyzed data, KSR performed experiments and 15 analyzed data and wrote an early version of the manuscript, JFP performed experiments, ZUK 16 provided D5 receptor antibodies, YS designed and supervised experiments, and edited the 17 manuscript, TW designed and supervised experiments, and edited the manuscript. 18
منابع مشابه
Localization and function of dopamine receptors in the subthalamic nucleus of normal and parkinsonian monkeys.
The subthalamic nucleus (STN) receives a dopaminergic innervation from the substantia nigra pars compacta, but the role of this projection remains poorly understood, particularly in primates. To address this issue, we used immuno-electron microscopy to localize D1, D2, and D5 dopamine receptors in the STN of rhesus macaques and studied the electrophysiological effects of activating D1-like or D...
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A critical role of the subthalamic nucleus (STN) in the control of movement has been proposed based on the observations that its lesion or high-frequency stimulation, aimed at altering its activity, is effective in alleviating clinical features of Parkinson’s disease (Bergman et al,. 1990; Bennazouz et al., 1993; Pollak et al., 1993, Benazzouz et al., 2000). Indeed, overactivity of the subthala...
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